To gain the advantage over by cunning; outwit.(verb-transitive)
American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Use "outsmart" in a sentence
"Plus he's a smug know-it-all brat who shouts down or tries to intimidate anyone he can't outsmart, which is almost anyone."
"While all varieties of influenza are RNA-type viruses that attack the respiratory system, the molecular biology of each virus mutates frequently, effectively trying to "outsmart" those of us physicians and scientists who strive to keep the virus at bay."
"For it is not they that outsmart us, but the capacity of genetic mutations to mimic intelligence in a way that can "outsmart" even "intelligent designers" such as human drug researchers."