Definition of "ectodomain" [ectodomain]

• The portion of a polypeptide on a cell membrane that extends beyond the membrane into the extracellular space. (noun)

Wiktionary.org : Text is available under the Creative Commons Attribution-ShareAlike License

• "EGFR signalling is preceded by receptor dimerization, typically thought to result from a ligand-induced conformational change in the ectodomain that exposes a loop (dimerization arm) required for receptor association."
• "Figure 1, most, but not all, antibodies inhibited binding of the Notch1 ectodomain to immobilized DLL4."
• "Our novel results support a model of autocrine/paracrine stimulation of cell motility in glioma cells by a cleaved L1 ectodomain and/or released exosomal vesicles containing L1."