Depression of spirits from loss of hope, confidence, or courage; dejection.(noun)
American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Use "despondency" in a sentence
"The second reason for the despondency is the realization that this, at last, is a direct clash between the two giants."
"Earlier, fruitless chemotherapeutic experiments often resulted in despondency, but now even the most pessimistic have gradually come to see the value of the results achieved."
"The powers which I feel, and of which I have given promise, may mature, may stamp themselves in act; but the spirit of despondency is strong upon the future exile, and I fear they never will."