Any substance that causes depletion of something(noun)
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Use "depleter" in a sentence
"- Helped secure an accelerated international schedule for the phase-out of methyl bromide, a leading ozone depleter."
""Food processing facilities in the United States are replacing whole structure treatments with methyl bromide (MB) - an ozone depleter, with treatments using sulfuryl fluoride (SF) and heat," said Zhu, who is a professor of entomology at K-State and a principal investigator on the project."
"Alternative to trichloroethane and trichloroethylene is neither an ozone depleter nor a carcinogen and has gained Boeing and Airbus approval on top of critical cleaning performance."