In, at, or toward the source of a stream: paddling upstream.
In a direction opposite to that of a stream's current: upstream traffic.
Business Closer to the point of production or manufacture than to the point of sale.
American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.