Definition of "sphingosine" []

• A basic, long-chain, unsaturated amino alcohol, C18H37NO2, found combined with lipids in the brain and in nerve tissue. (noun)

American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

• "Gilenya (fingolimod), licensed from Mitsubishi Tanabe Pharma Corporation, is the first in a new class of drugs that modulates sphingosine 1-phosphate (S1P) receptors[1],[2]."
• "The contribution of DNL-derived FA to ceramide synthesis was evaluated based on deuterium labeling of sphingosine - and acyl-groups (D), whereas non-DNL derived FA is illustrated with a blue column on the bottom of each bar."
• "In addition, our data show that DNL contributed relatively less stearoyl - than sphingosine-moiety to muscle c18 ceramide, suggesting that low SCD1 activity in muscle could be responsible for the increased dependency of muscle ceramide accumulation on dietary fat."