Definition of "ochronosis" [ochronosis]

• An autosomal-recessive metabolic disorder that causes an excess of homogentisic acid, resulting in adverse pigmentation, calcification, and inflammation of cartilaginous and related tissue throughout the body. (noun)

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• "Alkaptonuria (also known as ochronosis) is a genetic disorder characterised by the accumulation of homogentisic acid deposits in connective tissue."
• "In fact, the FDA proposed a ban on over-the-counter sales of hydroquinone in 2006 because too strong a dose or using even a lower dose for an extended period of time causes side effects such as darkening and thickening of the skin exogenous ochronosis."
• "Hydroquinone, a skin-lightening cream, can be effective, but be careful to use the dosage prescribed by your doctor—a high percentage of hydroquinone can cause ochronosis, an even darker discoloration of the skin."