Informal Used as a familiar term of address for a young woman or girl.(noun)
American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Use "missy" in a sentence
"Joe Scarborough seems to have an inside line that says missy is taking over Greta Whoever's spot."
"When I call missy, she completely ignores me unless she is hungry."
"Being called missy was another thing Eleanor hated."