Definition of "misfolding" [misfolding]

• Present participle of misfold. (verb)

Wiktionary.org : Text is available under the Creative Commons Attribution-ShareAlike License

• "The acquisition, announced last month without the disclosure of financial details, allows the drug giant to benefit from FoldRx's wide portfolio of clinical and pre-clinical programs for compounds studied as treatment for protein misfolding, which is increasingly recognized as an underlying cause in many chronic degenerative diseases."
• "FoldRx, based in Cambridge, Mass., is developing potential treatments for diseases caused by protein misfolding, which is increasingly recognized as an underlying cause in many chronic degenerative diseases."
• "In ATTR-CM, also known as Familial Amyloid Cardiomyopathy (FAC), a 'misfolding' of the protein transthyretin (TTR) causes an accumulation of protein-derived material known as amyloid fibrils in the myocardium."