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Definition of "methotrexate" [methotrexate]

  • A toxic antimetabolite, C20H22N8O5, that acts as a folic acid antagonist to interfere with cellular reproduction and is used in the treatment of psoriasis, certain cancers, and certain inflammatory diseases such as rheumatoid arthritis. (noun)

American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

Use "methotrexate" in a sentence
  • "An intravenous IV infusion of a medication called methotrexate may be used to abort the pregnancy or may be combined with surgery to ensure the full removal of pregnancy tissues."
  • "I had to terminate an ectopic pregnancy using methotrexate, which is the lowest risk way to treat the condition but that some misogynist in the Catholic church has declared to be impermissible abortion."
  • "Another drug, called methotrexate, can also be used with misoprostol, but it works slightly differently, halting the ongoing process of implantation, and is usually administered via injection."