Definition of "isoform" [isoform]

• Any of several different forms of the same protein, arising from either single nucleotide polymorphisms, differential splicing of mRNA, or post-translational modifications (e.g. sulfation, glycosylation, etc.) (noun)

Wiktionary.org : Text is available under the Creative Commons Attribution-ShareAlike License

• "The first test, called the "isoform approach" was introduced in 2004."
• "The longer protein, termed isoform a, is the only form in brain, whereas both isoforms are present in all other tissues."
• "(85 percent) of prion diseases in humans can be attributed to a spontaneous structural conversion of the cellular prion protein: Originally dominated by alpha-helices as structural elements, the prion protein is transformed into its misfolded "scrapie" isoform which is dominated by accordion-like folded protein sheets, so called beta-sheets."