Definition of "isocitrate" [isocitrate]

• Any salt or ester of isocitric acid (noun)

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• "In experiments with tumor cells, the researchers reversed the effects of a mutation in a gene called isocitrate dehydrogenase-1 (IDH1) by replenishing a compound called α-ketoglutarate"
• "The interconversion of citrate and isocitrate by aconitate hydratase was shown to occur with complete retention of the proton transferred between C2and C3 but with no retention of the OH - between C3 and C2."
• "The enzyme isocitrate dehydrogenase 1 (IDH1), which normally facilitates production of the metabolite {alpha} - ketoglutarate, is mutated in approximately 80% of secondary brain tumors."