Definition of "hypomorphic" [hypomorphic]

• Causing a partial loss of gene function. (adjective)

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• "Taken together, these two latter findings have challenged the concept that Wnt signalling in osteoblasts is a key pathway for the regulation of bone formation, which was further underscored by the finding that the osteopenia of rs/rs mice, carrying a hypomorphic mutation of the Wnt co-receptor Lrp6, is caused by increased bone resorption"
• "However, it did cause the formation of hypomorphic limbs as a result of increased cellular condensation and apoptosis."
• "The inhibition of sonic hedgehog signaling with cyclopamine caused hypomorphic limbs (during development and regeneration) but did not affect the expression of BMP-2 and SOX-9."