To laugh heartily and boisterously.(verb-intransitive)
American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Use "guffaw" in a sentence
"My guffaw is muffled by the sound of Cheerios cascading to the floor."
"What has me chuckling, more of a borderline guffaw, is that because MS is so ridiculous about standards they need to call IE8’s actual standards compliant mode, “Super Standards!”"
"My sense of humor is typically not the sort that people "guffaw" at -- but I hope there will be a moment or two of amusement for those who are kind enough to read it."