To make hostile, unsympathetic, or indifferent; alienate.(verb-transitive)
To remove from an accustomed place or set of associations.(verb-transitive)
American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Use "estrange" in a sentence
"He does not want to "estrange" the son he sees only several times a year."
"And home ends up being an old mansion with her hypochondriac of a mother and estrange half-sister."
"I'm taking her hat off, in the rain, her hair spills like spinach all the way down to her backpack, the top pocket where the bowl and the cinnamon estrange themselves from the coffee."