Definition of "amrinone" []

• A type 3 pyridine phosphodiesterase inhibitor used to treat congestive heart failure. (noun)
• Former name for inamrinone (changed in 2000 to avoid confusion with amiodarone). (noun)

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• "There have been no studies of amrinone in patients with sepsis."
• "We, therefore, hypothesized that endotoxin induced renal injury by activating phosphodiesterase 3 (PDE3) which metabolizes cAMP and that amrinone an inhibitor of PDE3 would prevent the renal injury."
• "Interaction of L-Arginine Phosphodiesterase Inhibitors in Vasodilation of the Porcine Internal Mammary Artery We tested the hypothesis that L-arginine (the substrate for nitric oxide production) - combined with amrinone, milrinone (Type III phosphodiesterase [PDE] inhibitors),"